When scientists find a way to shrink humans to five inches tall, Paul Safrane and his wife Audrey decide to ditch their stressed out lives in order to get small and live large in a luxurious downsized community. Filled with life-changing adventures and endless possibilities, Leisureland offers more than riches, as Paul discovers a whole new world and realizes that we are meant for something bigger.

As Ms. Frizzle leads the way, the class takes an action-packed journey through Arnold's digestive system (For lunch), a pulsating excursion through Ralphie's bloodstream (Inside Ralphie) and an exciting exploration through the Ralphiebot Robot to learn about bones, joints and muscles (Flexes its muscles).

Hop on the Thinga-ma-jigger with Sally and Nick and learn all about the skin we are in, the bones we own, our beating hearts why our tummies rumble, what causes sneezing.

Students at a quantum academy attempt to create a collective consciousness, only to discover that they themselves are part of a greater experiment.